Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2&#945;/ATF4/CHOP Signaling Pathway.

Li, Yueyong; Zhang, Yingjun; Fu, Huangde; Huang, Huadong; Lu, Qifeng; Qin, Houji; Wu, Yingning; Huang, Huatuo; Mao, Guizhen; Wei, Zhongheng; Liao, Pinhu

Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway.

Li, Yueyong; Zhang, Yingjun; Fu, Huangde; Huang, Huadong; Lu, Qifeng; Qin, Houji; Wu, Yingning; Huang, Huatuo; Mao, Guizhen; Wei, Zhongheng; Liao, Pinhu.

Afiliación

Li Y; Department of Interventional Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Zhang Y; Department of Interventional Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Fu H; Department of Medical Imageology, Hunan University of Medicine, Huaihua, 418000, China.
Huang H; Department of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Lu Q; Department of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Qin H; Department of Emergency Intervention, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Wu Y; Department of Emergency Intervention, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Huang H; Department of Emergency Intervention, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Mao G; Department of Emergency Intervention, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Wei Z; Department of Emergency Intervention, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.
Liao P; Department of Emergency Intervention, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China. weizhongh1968@163.com.

Neurosci Bull ; 36(2): 134-142, 2020 Feb.

Article en En | MEDLINE | ID: mdl-31309426

Asunto(s)

Estrés del Retículo Endoplásmico/genética; Infarto de la Arteria Cerebral Media; Accidente Cerebrovascular/genética; Accidente Cerebrovascular/metabolismo; Factor de Transcripción HES-1/deficiencia; Factor de Transcripción Activador 4/metabolismo; Adenina/análogos & derivados; Adenina/farmacología; Animales; Apoptosis/genética; Encéfalo/patología; Factor 2 Eucariótico de Iniciación/metabolismo; Indoles/farmacología; Masculino; Ratones; Ratones Endogámicos C57BL; Transducción de Señal; Accidente Cerebrovascular/patología; Factor de Transcripción CHOP/metabolismo; eIF-2 Quinasa/metabolismo

Palabras clave

ER stress; Hes1; Ischemic stroke; PERK/eIF2α/ATF4/CHOP pathway; Transient MCAO

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Infarto de la Arteria Cerebral Media / Estrés del Retículo Endoplásmico / Factor de Transcripción HES-1 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurosci Bull Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google