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Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model.
Quartey, Q Q; Miller, R J; Pinsker, B L; Okoh, U J; Shipman, W D; George, B A; Nwizu, C C; Barnes, L A; Kerns, M L; Caffrey, J A; Aliu, O; Brown, I D; Succaria, F; Maynard, J P; Herbert, A S; Kang, S; Miller, L S; Okoye, G A; Byrd, A S.
Afiliación
  • Quartey QQ; University of Maryland School of Medicine, Baltimore, MD, USA.
  • Miller RJ; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Pinsker BL; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Okoh UJ; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Shipman WD; Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
  • George BA; Warren Alpert Medical School of Brown University, Providence, RI, USA.
  • Nwizu CC; Warren Alpert Medical School of Brown University, Providence, RI, USA.
  • Barnes LA; Stanford University School of Medicine, Stanford, CA, USA.
  • Kerns ML; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Caffrey JA; Department of, Plastic & Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Aliu O; Department of, Plastic & Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Brown ID; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Succaria F; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Maynard JP; Department of, Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Herbert AS; University of Maryland School of Medicine, Baltimore, MD, USA.
  • Kang S; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Miller LS; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Okoye GA; Department of, Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Byrd AS; Howard University College of Medicine, Washington, DC, USA.
Clin Exp Dermatol ; 45(2): 202-206, 2020 Mar.
Article en En | MEDLINE | ID: mdl-31322280
ABSTRACT
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hidradenitis Supurativa / Modelos Animales de Enfermedad / Xenoinjertos / Ratones Límite: Animals / Humans Idioma: En Revista: Clin Exp Dermatol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hidradenitis Supurativa / Modelos Animales de Enfermedad / Xenoinjertos / Ratones Límite: Animals / Humans Idioma: En Revista: Clin Exp Dermatol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos