Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model.
Clin Exp Dermatol
; 45(2): 202-206, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31322280
ABSTRACT
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hidradenitis Supurativa
/
Modelos Animales de Enfermedad
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Xenoinjertos
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Ratones
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Exp Dermatol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos