Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining <i>In Vivo</i> Antitumor Efficacy.

Peyser, Brian D; Hermone, Ann; Salamoun, Joseph M; Burnett, James C; Hollingshead, Melinda G; McGrath, Connor F; Gussio, Rick; Wipf, Peter

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy.

Peyser, Brian D; Hermone, Ann; Salamoun, Joseph M; Burnett, James C; Hollingshead, Melinda G; McGrath, Connor F; Gussio, Rick; Wipf, Peter.

Afiliación

Peyser BD; Computational Drug Development Group, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI, Bethesda, Maryland. brian.peyser@nih.gov.
Hermone A; Computational Drug Development Group, Developmental Therapeutics Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Salamoun JM; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Burnett JC; Computational Drug Development Group, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI, Bethesda, Maryland.
Hollingshead MG; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
McGrath CF; Biological Testing Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI, Bethesda, Maryland.
Gussio R; Computational Drug Development Group, Developmental Therapeutics Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Wipf P; Computational Drug Development Group, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI, Bethesda, Maryland.

Mol Cancer Ther ; 18(10): 1765-1774, 2019 10.

Article en En | MEDLINE | ID: mdl-31341033

Asunto(s)

Antineoplásicos/farmacología; Furanos/farmacología; Animales; Antineoplásicos/química; Arilsulfotransferasa/genética; Arilsulfotransferasa/metabolismo; Muerte Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Femenino; Furanos/química; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Ratones Endogámicos BALB C; Ratones Desnudos

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Furanos / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2019 Tipo del documento: Article

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