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p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model.
Martínez-Mármol, Ramón; Mohannak, Nika; Qian, Lei; Wang, Tong; Gormal, Rachel S; Ruitenberg, Marc J; Vanhaesebroeck, Bart; Coulson, Elizabeth J; Meunier, Frédéric A.
Afiliación
  • Martínez-Mármol R; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Mohannak N; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Qian L; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Wang T; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane 4072, Australia, and.
  • Gormal RS; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Ruitenberg MJ; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Vanhaesebroeck B; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane 4072, Australia, and.
  • Coulson EJ; Cell Signalling, University College London Cancer Institute, London WC1E 6DD, United Kingdom.
  • Meunier FA; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia, f.meunier@uq.edu.au e.coulson@uq.edu.au.
J Neurosci ; 39(40): 7976-7991, 2019 10 02.
Article en En | MEDLINE | ID: mdl-31363064
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor de Necrosis Tumoral alfa / Precursor de Proteína beta-Amiloide / Placa Amiloide / Encefalitis / Fosfatidilinositol 3-Quinasa Clase I / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurosci Año: 2019 Tipo del documento: Article País de afiliación: Australia
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor de Necrosis Tumoral alfa / Precursor de Proteína beta-Amiloide / Placa Amiloide / Encefalitis / Fosfatidilinositol 3-Quinasa Clase I / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurosci Año: 2019 Tipo del documento: Article País de afiliación: Australia