miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt-ß-catenin pathway.

Liu, Qiang; Guan, Yanlei; Li, Zhenhang; Wang, Yao; Liu, Yu; Cui, Run; Wang, Yunjie

Liu, Qiang; Guan, Yanlei; Li, Zhenhang; Wang, Yao; Liu, Yu; Cui, Run; Wang, Yunjie.

Afiliación

Liu Q; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Guan Y; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Li Z; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Wang Y; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Liu Y; Department of Cardiac Surgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Cui R; Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Wang Y; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.

J Exp Clin Cancer Res ; 38(1): 358, 2019 Aug 16.

Article en En | MEDLINE | ID: mdl-31419987

Asunto(s)

Neoplasias Encefálicas/patología; Transición Epitelial-Mesenquimal; Receptores Frizzled/metabolismo; Glioblastoma/patología; MicroARNs/genética; Proteínas Wnt/metabolismo; beta Catenina/metabolismo; Animales; Apoptosis; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Proliferación Celular; Estudios de Cohortes; Femenino; Estudios de Seguimiento; Receptores Frizzled/genética; Regulación Neoplásica de la Expresión Génica; Glioblastoma/genética; Glioblastoma/metabolismo; Humanos; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Persona de Mediana Edad; Pronóstico; Tasa de Supervivencia; Células Tumorales Cultivadas; Proteínas Wnt/genética; Ensayos Antitumor por Modelo de Xenoinjerto; beta Catenina/genética

Palabras clave

EMT; FZD7; GBM; Mesenchymal phenotype; Wntß-catenin pathway; miR-504

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma / MicroARNs / Proteínas Wnt / Beta Catenina / Receptores Frizzled / Transición Epitelial-Mesenquimal Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Exp Clin Cancer Res Año: 2019 Tipo del documento: Article País de afiliación: China

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