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Real-time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody product quality.
Powers, David N; Wang, Yifan; Fratz-Berilla, Erica J; Velugula-Yellela, Sai Rashmika; Chavez, Brittany; Angart, Phillip; Trunfio, Nicholas; Yoon, Seongkyu; Agarabi, Cyrus.
Afiliación
  • Powers DN; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, Maryland.
  • Wang Y; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Testing and Research, Division of Product Quality Research, Silver Spring, Maryland.
  • Fratz-Berilla EJ; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, Maryland.
  • Velugula-Yellela SR; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, Maryland.
  • Chavez B; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, Maryland.
  • Angart P; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, Maryland.
  • Trunfio N; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Product Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, Maryland.
  • Yoon S; Sartorius Stedim North America Inc, Corporate Research, Bohemia, NY.
  • Agarabi C; Department of Chemical Engineering, University of Massachusetts, Lowell, Massachusetts.
Biotechnol Prog ; 35(6): e2894, 2019 11.
Article en En | MEDLINE | ID: mdl-31425633
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Reactores Biológicos / Aminoácidos / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biotechnol Prog Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Reactores Biológicos / Aminoácidos / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biotechnol Prog Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article