Nerve size correlates with clinical severity in Charcot-Marie-Tooth disease 1A.
Muscle Nerve
; 60(6): 744-748, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31469427
ABSTRACT
INTRODUCTION:
Nerve cross-sectional area (CSA) is larger than normal in Charcot-Marie-Tooth disease 1A (CMT1A), although to a variable extent. We explored whether CSA is correlated with CMT clinical severity measured with neuropathy score version 2 (CMTNS2) and its examination subscore (CMTES2) in CMT1A.METHODS:
We assessed 56 patients with CMT1A (42 families). They underwent nerve conduction study (NCS) and nerve high-resolution ultrasound (HRUS) of the left median, ulnar, and fibular nerves.RESULTS:
Univariate analysis showed NCS and HRUS variables to be significantly correlated with CMTNS2 and CMTES2 and with each other. Multivariate analysis showed that ulnar motor nerve conduction velocity (ß -0.19) and fibular compound muscle action potential amplitude (-1.50) significantly influenced CMTNS2 and that median forearm CSA significantly influenced CMTNS2 (ß 5.29) and CMTES2 (4.28).DISCUSSION:
Nerve size is significantly associated with clinical scores in CMT1A, which suggests that it might represent a potential biomarker of CMT damage and progression.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Nervio Peroneo
/
Nervio Cubital
/
Enfermedad de Charcot-Marie-Tooth
/
Nervio Mediano
/
Conducción Nerviosa
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Muscle Nerve
Año:
2019
Tipo del documento:
Article
País de afiliación:
Italia