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A novel density-volume calcium score by non-contrast CT predicts coronary plaque burden on coronary CT angiography: Results from the MACS (Multicenter AIDS cohort study).
Nakanishi, Rine; Delaney, Joseph A; Post, Wendy S; Dailing, Christopher; Blaha, Michael J; Palella, Frank; Witt, Mallory; Brown, Todd T; Kingsley, Lawrence A; Osawa, Kazuhiro; Ceponiene, Indre; Nezarat, Negin; Rahmani, Sina; Kanisawa, Mitsuru; Jacobson, Lisa; Budoff, Matthew J.
Afiliación
  • Nakanishi R; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA; Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan. Electronic address: rine.n@med.toho-u.ac.jp.
  • Delaney JA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Post WS; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Dailing C; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA.
  • Blaha MJ; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Palella F; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Witt M; Division of HIV Medicine, Harbor UCLA Medical Center, Torrance, CA, USA.
  • Brown TT; Division of Endocrinology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Kingsley LA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Osawa K; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA.
  • Ceponiene I; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA.
  • Nezarat N; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA.
  • Rahmani S; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA.
  • Kanisawa M; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA.
  • Jacobson L; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Budoff MJ; Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA, USA.
J Cardiovasc Comput Tomogr ; 14(3): 266-271, 2020.
Article en En | MEDLINE | ID: mdl-31564631
ABSTRACT

BACKGROUND:

The purpose of this study is to determine if a new score calculated with coronary artery calcium (CAC) density and volume is associated with total coronary artery plaque burden and composition on coronary CT angiography (CCTA) compared to the Agatston score (AS).

METHODS:

We identified 347 men enrolled in the Multicenter AIDS cohort study who underwent contrast and non-contrast CCTs, and had CAC>0. CAC densities (mean Hounsfield Units [HU]) per plaque) and volumes on non-contrast CCT were measured. A Density-Volume Calcium score was calculated by multiplying the plaque volume by a factor based on the mean HU of the plaque (4, 3, 2 and 1 for 130-199, 200-299, 300-399, and ≥400HU). Total Density-Volume Calcium score was determined by the sum of these individual scores. The semi-quantitative partially calcified and total plaque scores (PCPS and TPS) on CCTA were calculated. The associations between Density-Volume Calcium score, PCPS and TPS were examined.

RESULTS:

Overall, 2879 CAC plaques were assessed. Multivariable linear regression models demonstrated a stronger association between the log Density-Volume Calcium score and both the PCPS (ß 0.99, 95%CI 0.80-1.19) and TPS (ß 2.15, 95%CI 1.88-2.42) compared to the log of AS (PCPS ß 0.77, 95%CI 0.61-0.94; TPS ß 1.70, 95%CI 1.48-1.94). Similar results were observed for numbers of PC or TP segments.

CONCLUSION:

The new CAC score weighted towards lower density demonstrated improved correlation with semi-quantitative PC and TP burden on CCTA compared to the traditional AS, which suggests it has utility as an alternative measure of atherosclerotic burden.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Angiografía Coronaria / Enfermedad Coronaria / Placa Aterosclerótica / Calcificación Vascular / Angiografía por Tomografía Computarizada Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Cardiovasc Comput Tomogr Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / RADIOLOGIA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Angiografía Coronaria / Enfermedad Coronaria / Placa Aterosclerótica / Calcificación Vascular / Angiografía por Tomografía Computarizada Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Cardiovasc Comput Tomogr Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / RADIOLOGIA Año: 2020 Tipo del documento: Article