Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents.

Ansari, Mahsa; Shokrzadeh, Mohammad; Karima, Saeed; Rajaei, Shima; Hashemi, Seyedeh Mahdieh; Mirzaei, Hassan; Fallah, Marjan; Emami, Saeed

Ansari, Mahsa; Shokrzadeh, Mohammad; Karima, Saeed; Rajaei, Shima; Hashemi, Seyedeh Mahdieh; Mirzaei, Hassan; Fallah, Marjan; Emami, Saeed.

Afiliación

Ansari M; Pharmaceutical Sciences Research Center, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Shokrzadeh M; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Karima S; Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
Rajaei S; Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
Hashemi SM; Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Mirzaei H; Pharmaceutical Sciences Research Center, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Fallah M; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Emami S; Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: semami@mazums.ac.ir.

Bioorg Chem ; 93: 103300, 2019 12.

Article en En | MEDLINE | ID: mdl-31586708

Asunto(s)

Antineoplásicos/síntesis química; Diseño de Fármacos; Triazoles/química; Animales; Antineoplásicos/metabolismo; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Sitios de Unión; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Colchicina/química; Colchicina/metabolismo; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Cinética; Ratones; Simulación del Acoplamiento Molecular; Unión Proteica; Estructura Terciaria de Proteína; Relación Estructura-Actividad; Triazoles/metabolismo; Triazoles/farmacología; Tubulina (Proteína)/química; Tubulina (Proteína)/metabolismo; Moduladores de Tubulina/síntesis química; Moduladores de Tubulina/metabolismo; Moduladores de Tubulina/farmacología

Palabras clave

3,4,5-trimethoxyphenyl; 4H-1,2,4-triazoles; Anticancer agents; Conformationally constrained; Cytotoxic activity

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triazoles / Diseño de Fármacos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: Irán

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