Consortia of bioactives in supercritical carbon dioxide extracts of mustard and small cardamom seeds lower serum cholesterol levels in rats: new leads for hypocholesterolaemic supplements from spices.

Chakraborty, Soumi; Paul, Kaninika; Mallick, Priyanka; Pradhan, Shrabani; Das, Koushik; Chakrabarti, Saikat; Nandi, Dilip Kumar; Bhattacharjee, Paramita

Chakraborty, Soumi; Paul, Kaninika; Mallick, Priyanka; Pradhan, Shrabani; Das, Koushik; Chakrabarti, Saikat; Nandi, Dilip Kumar; Bhattacharjee, Paramita.

Afiliación

Chakraborty S; Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata 700032, India.
Paul K; Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata 700032, India.
Mallick P; Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, India.
Pradhan S; Research Unit developed by Department of Physiology, Nutrition and Microbiology, Raja N.L. Khan Women's College, Midnapore 721102, West Bengal, India.
Das K; Research Unit developed by Department of Physiology, Nutrition and Microbiology, Raja N.L. Khan Women's College, Midnapore 721102, West Bengal, India.
Chakrabarti S; Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, India.
Nandi DK; Research Unit developed by Department of Physiology, Nutrition and Microbiology, Raja N.L. Khan Women's College, Midnapore 721102, West Bengal, India.
Bhattacharjee P; Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata 700032, India.

J Nutr Sci ; 8: e32, 2019.

Article en En | MEDLINE | ID: mdl-31595188

Asunto(s)

Dióxido de Carbono/química; Colesterol/sangre; Suplementos Dietéticos; Elettaria/química; Planta de la Mostaza/química; Semillas/química; Especias/análisis; Animales; Anticolesterolemiantes/análisis; Anticolesterolemiantes/farmacología; Antioxidantes/análisis; Antioxidantes/farmacología; Cromatografía con Fluido Supercrítico; Relación Dosis-Respuesta a Droga; Sinergismo Farmacológico; Inhibidores de Hidroximetilglutaril-CoA Reductasas/análisis; Inhibidores de Hidroximetilglutaril-CoA Reductasas/farmacología; Hipercolesterolemia/tratamiento farmacológico; Masculino; Simulación del Acoplamiento Molecular; Octoxinol/análisis; Octoxinol/farmacología; Extractos Vegetales/análisis; Extractos Vegetales/farmacología; Ratas; Ratas Wistar; Pruebas de Toxicidad Aguda

Palabras clave

AI, atherogenic index; BW, body weight; EDX, energy dispersive X-rays; EPR, electron paramagnetic resonance; FT-IR, Fourier transformed IR spectroscopy; GOLD, Genetic Optimization for Ligand Docking; HDL-C, HDL-cholesterol; HED, human equivalent dose; HMG-CoA reductase; HMG-CoA, 3-hydroxy-3-methyl-glutaryl-CoA; Hypocholesterolaemic activity; LC-ESI-MS, liquid chromatography-electrospray ionisation MS; LDL-C, LDL-cholesterol; OECD, Organization of Economic Co-operation and Development; PDB, protein data bank; SC, small cardamom; SC-CO2, supercritical CO2; SCbest, small cardamom seed extract obtained at the optimum conditions of SC-CO2; Small cardamom seeds; Supercritical carbon dioxide extraction; TC, total cholesterol; YM, yellow mustard; YMbest, yellow mustard seed extract obtained at the optimum conditions of SC-CO2; Yellow mustard seeds

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Semillas / Dióxido de Carbono / Colesterol / Especias / Suplementos Dietéticos / Elettaria / Planta de la Mostaza Límite: Animals Idioma: En Revista: J Nutr Sci Año: 2019 Tipo del documento: Article País de afiliación: India

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