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Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
Chatzopoulou, Maria; Claridge, Tim D W; Davies, Kay E; Davies, Stephen G; Elsey, David J; Emer, Enrico; Fletcher, Ai M; Harriman, Shawn; Robinson, Neil; Rowley, Jessica A; Russell, Angela J; Tinsley, Jonathon M; Weaver, Richard; Wilkinson, Isabel V L; Willis, Nicky J; Wilson, Francis X; Wynne, Graham M.
Afiliación
  • Chatzopoulou M; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Claridge TDW; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Davies KE; Department of Physiology, Anatomy and Genetics, MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford OX1 3PT, United Kingdom.
  • Davies SG; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Elsey DJ; Summit Therapeutics plc, 136a Eastern Avenue, Milton Park, Abingdon OX14 4SB, United Kingdom.
  • Emer E; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Fletcher AM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Harriman S; Summit Therapeutics plc, One Broadway, 14th Floor, Cambridge, Massachusetts 02142, United States.
  • Robinson N; S.H.B. Enterprises Ltd., 55 Station Road, Beaconsfield HP19 1QL, United Kingdom.
  • Rowley JA; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Russell AJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Tinsley JM; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3PQ, United Kingdom.
  • Weaver R; Summit Therapeutics plc, 136a Eastern Avenue, Milton Park, Abingdon OX14 4SB, United Kingdom.
  • Wilkinson IVL; XenoGesis Ltd., BioCity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, United Kingdom.
  • Willis NJ; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Wilson FX; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.
  • Wynne GM; Summit Therapeutics plc, 136a Eastern Avenue, Milton Park, Abingdon OX14 4SB, United Kingdom.
J Med Chem ; 63(5): 2547-2556, 2020 03 12.
Article en En | MEDLINE | ID: mdl-31599580
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzoxazoles / Distrofia Muscular de Duchenne / Utrofina / Naftalenos / Naftoles Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzoxazoles / Distrofia Muscular de Duchenne / Utrofina / Naftalenos / Naftoles Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido