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Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Powers, Rani K; Culp-Hill, Rachel; Ludwig, Michael P; Smith, Keith P; Waugh, Katherine A; Minter, Ross; Tuttle, Kathryn D; Lewis, Hannah C; Rachubinski, Angela L; Granrath, Ross E; Carmona-Iragui, María; Wilkerson, Rebecca B; Kahn, Darcy E; Joshi, Molishree; Lleó, Alberto; Blesa, Rafael; Fortea, Juan; D'Alessandro, Angelo; Costello, James C; Sullivan, Kelly D; Espinosa, Joaquin M.
Afiliación
  • Powers RK; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Culp-Hill R; Computational Bioscience Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Ludwig MP; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Smith KP; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Waugh KA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Minter R; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Tuttle KD; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Lewis HC; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Rachubinski AL; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Granrath RE; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Carmona-Iragui M; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Wilkerson RB; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Kahn DE; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Joshi M; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Lleó A; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autonoma de Barcelona, CIBERNED, Barcelona, Spain.
  • Blesa R; Barcelona Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain.
  • Fortea J; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • D'Alessandro A; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Costello JC; Functional Genomics Facility, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Sullivan KD; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autonoma de Barcelona, CIBERNED, Barcelona, Spain.
  • Espinosa JM; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autonoma de Barcelona, CIBERNED, Barcelona, Spain.
Nat Commun ; 10(1): 4766, 2019 10 18.
Article en En | MEDLINE | ID: mdl-31628327
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trisomía / Cromosomas Humanos Par 21 / Receptores de Interferón / Síndrome de Down / Quinurenina Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trisomía / Cromosomas Humanos Par 21 / Receptores de Interferón / Síndrome de Down / Quinurenina Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos