Neuroradiological Findings in the Spinocerebellar Ataxias.
Tremor Other Hyperkinet Mov (N Y)
; 92019.
Article
en En
| MEDLINE
| ID: mdl-31632837
ABSTRACT
Background:
The spinocerebellar ataxias (SCAs) are a group of autosomal dominant degenerative diseases characterized by cerebellar ataxia. Classified according to gene discovery, specific features of the SCAs - clinical, laboratorial, and neuroradiological (NR) - can facilitate establishing the diagnosis. The purpose of this study was to review the particular NR abnormalities in the main SCAs.Methods:
We conducted a literature search on this topic.Results:
The main NR characteristics of brain imaging (magnetic resonance imaging or computerized tomography) in SCAs were (1) pure cerebellar atrophy; (2) cerebellar atrophy with other findings (e.g., pontine, olivopontocerebellar, spinal, cortical, or subcortical atrophy; "hot cross bun sign", and demyelinating lesions); (3) selective cerebellar atrophy; (4) no cerebellar atrophy.Discussion:
The main NR abnormalities in the commonest SCAs, are not pathognomonic of any specific genotype, but can be helpful in limiting the diagnostic options. We are progressing to a better understanding of the SCAs, not only genetically, but also pathologically; NR is helpful in the challenge of diagnosing the specific genotype of SCA.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Ataxias Espinocerebelosas
/
Neuroimagen
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Tremor Other Hyperkinet Mov (N Y)
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil