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Association between oestrogen receptors and female temporomandibular disorders.
Küchler, Erika Calvano; Meger, Michelle Nascimento; Ayumi Omori, Marjorie; Gerber, Jennifer Tsi; Carneiro Martins Neto, Evandro; Silva Machado, Nilza Cristina da; Cavalcante, Rafael Corrêa; Teixeira, Lucas Ribeiro; Stuani, Maria Bernadete; Nelson Filho, Paulo; da Costa, Delson João; Souza, Juliana Feltrin de; Brancher, João Armando; León, Jorge Esquiche; Scariot, Rafaela.
Afiliación
  • Küchler EC; Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil.
  • Meger MN; Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil.
  • Ayumi Omori M; Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil.
  • Gerber JT; Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil.
  • Carneiro Martins Neto E; Department of Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil.
  • Silva Machado NCD; Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil.
  • Cavalcante RC; Department of Oral and Maxillofacial Surgery, Universidade Federal Do Paraná, Curitiba, Brazil.
  • Teixeira LR; Department of Oral Biology, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil.
  • Stuani MB; Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil.
  • Nelson Filho P; Department of Pediatric Dentistry, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil.
  • da Costa DJ; Department of Oral and Maxillofacial Surgery, Universidade Federal Do Paraná, Curitiba, Brazil.
  • Souza JF; Department of Pediatric Dentistry, Universidade Federal Do Paraná, Curitiba, Brazil.
  • Brancher JA; Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil.
  • León JE; Department of Oral Pathology, Ribeirão Preto Dental School, Universidade de São Paulo, Ribeirão Preto, Brazil.
  • Scariot R; Department of Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Brazil.
Acta Odontol Scand ; 78(3): 181-188, 2020 Apr.
Article en En | MEDLINE | ID: mdl-31646926
Objective: To evaluate if temporomandibular disorders (TMDs) are associated with genetic polymorphisms in ESR1 and ESR2, which are genes encoding oestrogen receptor alpha (ERα) and beta (ERß). Also, we included an animal model to check if ERα and ERß are expressed in the temporomandibular joint (TMJ) during adolescence.Materials and methods: A total of 139 teenagers and 93 adults were diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMDs). The DNA was collected and the markers ESR1 and ERS2 were genotyped. Additionally, immunohistochemistry was performed in TMJ tissues from female Wistar rats during puberty. All data were submitted to statistical analysis with confidence interval of 95%.Results: Teenagers presented more disc displacement and arthralgia than adults (p < .05). The genetic polymorphism rs1256049 in ESR2 was associated with disc displacement (p = .040; OR = 10.50/95%CI 1.17-98.74) and arthralgia (p = .036; OR = 7.20/95%CI 1.10-46.88) in adults. The ERα and ERß are expressed in rat TMJ tissues.Conclusions: We provide evidence that ESR2 is associated with TMD and could be a genetic marker for this condition in adult women. Furthermore, oestrogens receptors are presented in TMJ of adolescent female rats.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Articulación Temporomandibular / Trastornos de la Articulación Temporomandibular / Receptores de Estrógenos / Artralgia / Receptor alfa de Estrógeno / Receptor beta de Estrógeno Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male Idioma: En Revista: Acta Odontol Scand Año: 2020 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Articulación Temporomandibular / Trastornos de la Articulación Temporomandibular / Receptores de Estrógenos / Artralgia / Receptor alfa de Estrógeno / Receptor beta de Estrógeno Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male Idioma: En Revista: Acta Odontol Scand Año: 2020 Tipo del documento: Article País de afiliación: Brasil