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Serum Level and Activity of Butylcholinesterase: A Biomarker for Post-Stroke Dementia.
Chen, Yi-Chun; Chou, Wen-Hai; Fang, Chiu-Ping; Liu, Tung-Hsia; Tsou, Hsiao-Hui; Wang, Yun; Liu, Yu-Li.
Afiliación
  • Chen YC; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. ycchen.cgmh@gmail.com.
  • Chou WH; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan. ycchen.cgmh@gmail.com.
  • Fang CP; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan. eikon@nhri.org.tw.
  • Liu TH; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan. wenliu@nhri.org.tw.
  • Tsou HH; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 35053, Taiwan. 940903@nhri.org.tw.
  • Wang Y; Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung 44047, Taiwan. 940903@nhri.org.tw.
  • Liu YL; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan. 020120@nhri.edu.tw.
J Clin Med ; 8(11)2019 Oct 24.
Article en En | MEDLINE | ID: mdl-31653081
Cholinergic neurotransmission regulates the immune response and inhibits cytokine release after stroke. The changes in the level/activity of blood cholinesterase (ChE) in patients with post-stroke dementia (PSD) are less known. This study aimed to examine post-stroke plasma acetylcholinesterase (AChE) and butylcholinesterase (BChE) and determine whether they are biomarkers for PSD. Thirty patients with PSD, 87 post-stroke patients without dementia (PSNoD), and 117 age- and gender-matched healthy controls were recruited. Missense genetic variants AChE rs1799806 and BChE rs1803274 were genotyped. The plasma AChE level did not differ between the PSD and PSNoD groups. However, BChE levels were significantly lower in the PSD than in the PSNoD group (3300.66 ± 515.35 vs 3855.74 ± 677.60 ng/mL, respectively; p = 0.0033). The activities of total ChE, BChE, and AChE were all lower in the PSD group (19,563.33 ± 4366.03, 7650.17 ± 1912.29, 11,913.17 ± 2992.42 mU/mL, respectively) than in the PSNoD group (23,579.08 ± 5251.55, 9077.72 ± 1727.28, and 14,501.36 ± 4197.17 mU/mL, respectively). When further adjusting for age and sex, significance remained in BChE level and activity and in total ChE activity. BChE rs1803274 was associated with reduced BChE activity, while AChE rs1799806 did not influence AChE activity. The level and activity of BChE, but not of AChE, were decreased in PSD patients and may therefore aid in PSD diagnosis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2019 Tipo del documento: Article País de afiliación: Taiwán

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2019 Tipo del documento: Article País de afiliación: Taiwán