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Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Mancuso, Renzo; Van Den Daele, Johanna; Fattorelli, Nicola; Wolfs, Leen; Balusu, Sriram; Burton, Oliver; Liston, Adrian; Sierksma, Annerieke; Fourne, Yannick; Poovathingal, Suresh; Arranz-Mendiguren, Amaia; Sala Frigerio, Carlo; Claes, Christel; Serneels, Lutgarde; Theys, Tom; Perry, V Hugh; Verfaillie, Catherine; Fiers, Mark; De Strooper, Bart.
Afiliación
  • Mancuso R; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium. renzo.mancuso@kuleuven.vib.be.
  • Van Den Daele J; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium. renzo.mancuso@kuleuven.vib.be.
  • Fattorelli N; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Wolfs L; Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven Stem Cell Institute, Leuven, Belgium.
  • Balusu S; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
  • Burton O; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Liston A; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
  • Sierksma A; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Fourne Y; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
  • Poovathingal S; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Arranz-Mendiguren A; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
  • Sala Frigerio C; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Claes C; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
  • Serneels L; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Theys T; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
  • Perry VH; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • Verfaillie C; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
  • Fiers M; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.
  • De Strooper B; Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.
Nat Neurosci ; 22(12): 2111-2116, 2019 12.
Article en En | MEDLINE | ID: mdl-31659342
Although genetics highlights the role of microglia in Alzheimer's disease, one-third of putative Alzheimer's disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer's disease risk genes. Oligomeric amyloid-ß induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microglía / Células Madre Embrionarias / Enfermedad de Alzheimer / Transcriptoma Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microglía / Células Madre Embrionarias / Enfermedad de Alzheimer / Transcriptoma Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Bélgica