Metabolism of Glycogen in Brain White Matter.
Adv Neurobiol
; 23: 187-207, 2019.
Article
en En
| MEDLINE
| ID: mdl-31667810
ABSTRACT
Brain glycogen is a specialized energy buffer, rather than a conventional reserve. In the rodent optic nerve, a central white matter tract, it is located in astrocytes, where it is converted to lactate, which is then shuttled intercellularly from the astrocyte to the axon. This basic pathway was elucidated from non-physiological experiments in which the nerve was deprived of exogenous glucose. However, this shuttling also occurs under physiological conditions, when tissue energy demand is increased above baseline levels in the presence of normoglycemic concentrations of glucose. The signaling mechanism by which axons alert astrocytes to their increased energy requirement is likely to be elevated interstitial K+, the inevitable consequence of increased neuronal activity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sustancia Blanca
/
Glucógeno
Límite:
Animals
Idioma:
En
Revista:
Adv Neurobiol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Reino Unido