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Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.
Lu, Tianbao; Connolly, Peter J; Philippar, Ulrike; Sun, Weimei; Cummings, Maxwell D; Barbay, Kent; Gys, Luc; Van Nuffel, Luc; Austin, Nigel; Bekkers, Mariette; Shen, Fang; Cai, Ann; Attar, Ricardo; Meerpoel, Lieven; Edwards, James.
Afiliación
  • Lu T; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States. Electronic address: tlu3@its.jnj.com.
  • Connolly PJ; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
  • Philippar U; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Sun W; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
  • Cummings MD; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
  • Barbay K; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
  • Gys L; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Van Nuffel L; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Austin N; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Bekkers M; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Shen F; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
  • Cai A; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
  • Attar R; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
  • Meerpoel L; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Edwards J; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, United States.
Bioorg Med Chem Lett ; 29(23): 126743, 2019 12 01.
Article en En | MEDLINE | ID: mdl-31678006
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Descubrimiento de Drogas / Proteína 1 de la Translocación del Linfoma del Tejido Linfático Asociado a Mucosas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Descubrimiento de Drogas / Proteína 1 de la Translocación del Linfoma del Tejido Linfático Asociado a Mucosas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article