Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning.
J Biomed Sci
; 26(1): 91, 2019 Nov 07.
Article
en En
| MEDLINE
| ID: mdl-31699087
ABSTRACT
BACKGROUND:
Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available.METHODS:
Herein, starting from the identification of 122 genetic loci related to FSS, we adopted a genetic-driven drug discovery bioinformatics pipeline based on functional annotation to prioritize crucial biological FSS-related genes. These genes were suggested to be potential targets for therapeutics.RESULTS:
We discovered five druggable subnetworks, which contained seven FSS-related genes and 17 druggable targerts.CONCLUSIONS:
This study provides a valuable drug repositioning accompanied by corresponding targetable gene clusters for FSS therapy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estatura
/
Predisposición Genética a la Enfermedad
/
Descubrimiento de Drogas
/
Reposicionamiento de Medicamentos
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Child
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Child, preschool
/
Female
/
Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
J Biomed Sci
Asunto de la revista:
MEDICINA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Taiwán