Your browser doesn't support javascript.
loading
Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria.
Castelletto, Valeria; Edwards-Gayle, Charlotte J C; Hamley, Ian W; Barrett, Glyn; Seitsonen, Jani; Ruokolainen, Janne; de Mello, Lucas Rodrigues; da Silva, Emerson Rodrigo.
Afiliación
  • Castelletto V; Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK. I.W.Hamley@reading.ac.uk.
  • Edwards-Gayle CJC; Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK. I.W.Hamley@reading.ac.uk.
  • Hamley IW; Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK. I.W.Hamley@reading.ac.uk.
  • Barrett G; School of Biological Sciences, University of Reading, Reading RG6 6UR, UK.
  • Seitsonen J; Nanomicroscopy Center, Aalto University, Puumiehenkuja 2, FIN-02150 Espoo, Finland.
  • Ruokolainen J; Nanomicroscopy Center, Aalto University, Puumiehenkuja 2, FIN-02150 Espoo, Finland.
  • de Mello LR; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04023062, Brazil.
  • da Silva ER; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04023062, Brazil.
Chem Commun (Camb) ; 56(4): 615-618, 2020 Jan 14.
Article en En | MEDLINE | ID: mdl-31833497
ABSTRACT
Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Arginina / Pseudomonas aeruginosa / Antibacterianos Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Arginina / Pseudomonas aeruginosa / Antibacterianos Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido