Dodelates A-E: Five dimeric eudesmane sesquiterpenoids from Dobinea delavayi.

Shen, Yi; Chen, Hao; Shen, Lei; Li, Hua-Xuan; Dong, Xiang; Xiao, Chao-Jiang; Jiang, Bei

Shen, Yi; Chen, Hao; Shen, Lei; Li, Hua-Xuan; Dong, Xiang; Xiao, Chao-Jiang; Jiang, Bei.

Afiliación

Shen Y; Institute of Materia Medica, Dali University, Dali 671000, PR China; College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China.
Chen H; College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China.
Shen L; College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China.
Li HX; College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China.
Dong X; Institute of Materia Medica, Dali University, Dali 671000, PR China; College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China.
Xiao CJ; College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China. Electronic address: xiaochaojiang@yeah.net.
Jiang B; Institute of Materia Medica, Dali University, Dali 671000, PR China. Electronic address: jiangbei@dali.edu.cn.

Bioorg Chem ; 95: 103488, 2020 01.

Article en En | MEDLINE | ID: mdl-31884146

ABSTRACT

ABSTRACT

Dodelates A-E (1-5), five angeloylated eudesmane sesquiterpenoid dimers were isolated from the roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses. A possible biosynthetic pathway of these five compounds was proposed. Compounds 1 and 3 exhibited moderate antimalarial activities against Plasmodium yoelii BY265RFP.

Asunto(s)

Antimaláricos/farmacología; Malaria/tratamiento farmacológico; Plantas Medicinales/química; Plasmodium yoelii/efectos de los fármacos; Sapindaceae/química; Sesquiterpenos de Eudesmano/farmacología; Animales; Antimaláricos/química; Antimaláricos/aislamiento & purificación; Cristalografía por Rayos X; Relación Dosis-Respuesta a Droga; Ratones; Ratones Endogámicos; Modelos Moleculares; Estructura Molecular; Pruebas de Sensibilidad Parasitaria; Raíces de Plantas/química; Sesquiterpenos de Eudesmano/química; Sesquiterpenos de Eudesmano/aislamiento & purificación; Relación Estructura-Actividad

Palabras clave

Anacardiaceae; Antimalarial activity; Dimeric eudesmane sesquiterpenoids; Dobinea delavayi

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plantas Medicinales / Plasmodium yoelii / Sapindaceae / Sesquiterpenos de Eudesmano / Malaria / Antimaláricos Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article

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