Stabilizing HIF to Ameliorate Anemia.
Cell
; 180(1): 6, 2020 01 09.
Article
en En
| MEDLINE
| ID: mdl-31951520
ABSTRACT
Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chronic kidney disease (CKD).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor 1 Inducible por Hipoxia
/
Glicina
/
Anemia
/
Isoquinolinas
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos