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Serum elimination half-lives adjusted for ongoing exposure of tri-to hexabrominated diphenyl ethers: Determined in persons moving from North America to Australia.
Sjödin, Andreas; Mueller, Jochen F; Jones, Richard; Schütze, Andre; Wong, Lee-Yang; Caudill, Samuel P; Harden, Fiona A; Webster, Thomas F; Toms, Leisa-Maree.
Afiliación
  • Sjödin A; Centers for Disease Control and Prevention (CDC), National Center for Environmental Health (NCEH), Division of Laboratory Sciences (DLS), 4770 Buford Hwy NE, Atlanta, GA, 30341, USA. Electronic address: asjodin@cdc.gov.
  • Mueller JF; Queensland Alliance for Environmental Health Science (QAEHS), The University of Queensland, 20 Cornwall Street Woolloongabba, 4102, Queensland, Australia.
  • Jones R; Centers for Disease Control and Prevention (CDC), National Center for Environmental Health (NCEH), Division of Laboratory Sciences (DLS), 4770 Buford Hwy NE, Atlanta, GA, 30341, USA.
  • Schütze A; Centers for Disease Control and Prevention (CDC), National Center for Environmental Health (NCEH), Division of Laboratory Sciences (DLS), 4770 Buford Hwy NE, Atlanta, GA, 30341, USA.
  • Wong LY; Centers for Disease Control and Prevention (CDC), National Center for Environmental Health (NCEH), Division of Laboratory Sciences (DLS), 4770 Buford Hwy NE, Atlanta, GA, 30341, USA.
  • Caudill SP; Centers for Disease Control and Prevention (CDC), National Center for Environmental Health (NCEH), Division of Laboratory Sciences (DLS), 4770 Buford Hwy NE, Atlanta, GA, 30341, USA.
  • Harden FA; Hunter Industrial Medicine, Maitland, Australia.
  • Webster TF; Dept Environmental Health, Boston University School of Public Health, Boston, MA, 02130, USA.
  • Toms LM; School of Public Health and Social Work, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
Chemosphere ; 248: 125905, 2020 Jun.
Article en En | MEDLINE | ID: mdl-32004881
ABSTRACT
The objective of the study was to determine the human serum elimination half-life of polybrominated diphenyl ethers (PBDEs) adjusted for ongoing exposure in subjects moving from a higher exposure region (North America) to a lower exposure region (Australia). The study population was comprised of exchange students and long-term visitors from North America moving to Brisbane, Australia (N = 27) and local residents (N = 23) who were followed by repeated serum sampling every other month. The local residents were sampled to adjust for ongoing exposure in Australia. Only one visitor remained in Australia for a period of time similar to the elimination half-life and had a sufficiently high initial concentration of PBDEs to derive a half-life. This visitor arrived in Australia in March of 2011 and remained in the country for 1.5 years. Since the magnitude of PBDE exposure is lower in Australia than in North America we observed an apparent 1st order elimination curve over time from which we have estimated the serum elimination half-lives for BDE28, BDE47, BDE99, BDE100, and BDE153 to be 0.942, 1.19, 1.03, 2.16, and 4.12 years, respectively. Uncertainty in the estimates were estimated using a Monte Carlo simulation. The human serum elimination half-life adjusted for ongoing exposure can allow us to assess the effectiveness and reduction in exposure in the general population following phase out of commercial penta- and octaBDE in 2004 in the United States.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Éteres Difenilos Halogenados Tipo de estudio: Observational_studies Límite: Adult / Humans País/Región como asunto: America do norte / Oceania Idioma: En Revista: Chemosphere Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Éteres Difenilos Halogenados Tipo de estudio: Observational_studies Límite: Adult / Humans País/Región como asunto: America do norte / Oceania Idioma: En Revista: Chemosphere Año: 2020 Tipo del documento: Article