Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing.

Gaber, Timo; Brinkman, Antonia Clara Katharina; Pienczikowski, Justyna; Diesing, Karoline; Damerau, Alexandra; Pfeiffenberger, Moritz; Lang, Annemarie; Ohrndorf, Sarah; Burmester, Gerd-Rüdiger; Buttgereit, Frank; Hoff, Paula

Gaber, Timo; Brinkman, Antonia Clara Katharina; Pienczikowski, Justyna; Diesing, Karoline; Damerau, Alexandra; Pfeiffenberger, Moritz; Lang, Annemarie; Ohrndorf, Sarah; Burmester, Gerd-Rüdiger; Buttgereit, Frank; Hoff, Paula.

Afiliación

Gaber T; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany.
Brinkman ACK; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.
Pienczikowski J; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany.
Diesing K; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.
Damerau A; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany.
Pfeiffenberger M; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.
Lang A; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany.
Ohrndorf S; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.
Burmester GR; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany.
Buttgereit F; German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.
Hoff P; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany.

Int J Mol Sci ; 21(3)2020 Jan 29.

Article en En | MEDLINE | ID: mdl-32013232

Asunto(s)

Inhibidores de las Cinasas Janus/farmacología; Quinasas Janus/metabolismo; Osteogénesis/efectos de los fármacos; Piperidinas/farmacología; Pirimidinas/farmacología; Pirroles/farmacología; Diferenciación Celular/efectos de los fármacos; Hipoxia de la Célula; Movimiento Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Células Cultivadas; Condrogénesis/efectos de los fármacos; Colágeno Tipo I/metabolismo; Cadena alfa 1 del Colágeno Tipo I; Subunidad alfa 1 del Factor de Unión al Sitio Principal/metabolismo; Humanos; Quinasas Janus/antagonistas & inhibidores; Células Madre Mesenquimatosas/citología; Células Madre Mesenquimatosas/metabolismo

Palabras clave

bone healing; chondrogenic differentiation; hMSC-migration; osteoclast differentiation; osteogenic differentiation; tofacitinib

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteogénesis / Piperidinas / Pirimidinas / Pirroles / Quinasas Janus / Inhibidores de las Cinasas Janus Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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