Live Birth in Sex-Reversed XY Mice Lacking the Nuclear Receptor Dax1.
Sci Rep
; 10(1): 1703, 2020 02 03.
Article
en En
| MEDLINE
| ID: mdl-32015477
ABSTRACT
The nuclear hormone receptor Dax1 functions during development as a testes-determining gene. However, the phenotype of male mice lacking Dax1 is strain-dependent due to the background-specific abundance of male-determining Sry gene-transcripts. We hypothesised that inter-individual variation in Sry mRNA-abundance would result in a spectrum of phenotypes even within-strain. We found that while all XY C57BL/6J mice lacking Dax1 presented as phenotypic females, there was a marked inter-individual variability in measures of fertility. Indeed, we report rare occasions where sex-reversed mice had measures of fertility comparable to those in control females. On two occasions, these sex-reversed XY mice were able to give birth to live offspring following mating to stud-males. As such, this work documents within-strain variability in phenotypes of XY mice lacking Dax1, and reports for the first time a complete sex-reversal capable of achieving live birth in these mice.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos del Desarrollo Sexual
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Testículo
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Procesos de Determinación del Sexo
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Proteína de la Región Y Determinante del Sexo
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Receptor Nuclear Huérfano DAX-1
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Sci Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido