Correlation between polymorphisms in IGF2/H19 gene locus and epithelial ovarian cancer risk in Chinese population.
Genomics
; 112(3): 2510-2515, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32045670
ABSTRACT
To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related with EOC risk. Specifically, the minor allele C of rs2525885 and allele A of rs2839698 was associated with elevated EOC genetic susceptibility under both dominant and recessive models (TC + CC vs TT adjusted OR 1.61, P = .031; CC vs TT + TC adjusted OR 4.87, P = .014; GA + AA vs GG adjusted OR 1.63, P = .023; AA vs GG + GA adjusted OR 2.43, P = .007). For rs3741206, the genotype TC + CC was associated with a significant decrease in EOC risk with the TT genotype as reference in a dominant genetic model (adjusted OR 0.44, P = .003), while for rs3741219, genotype AA was associated with a 59% decrease in EOC risk only in the recessive model (adjusted OR 0.41, P = .038). In the stratified analysis, an increased risk associated with the variant genotypes was observed in only subjects aged >47 years for rs2525885 (adjusted OR = 2.04, P = .024), rs2839698 (adjusted OR = 2.50, P = .047) and rs3741206 (adjusted OR = 0.37, P = .009), respectively. What's more, the TC + CC genotype of rs2525885 was significantly associated with advanced FIGO stage (III vs II, adjusted OR = 2.73, P = .040).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
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Factor II del Crecimiento Similar a la Insulina
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Polimorfismo de Nucleótido Simple
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ARN Largo no Codificante
/
Carcinoma Epitelial de Ovario
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Genomics
Asunto de la revista:
GENETICA
Año:
2020
Tipo del documento:
Article