Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.

Liu, Zheng; Qiu, Xiaoling; Mak, Shinghung; Guo, Baojian; Hu, Shengquan; Wang, Jiajun; Luo, Fangcheng; Xu, Daping; Sun, Yewei; Zhang, Gaoxiao; Cui, Guozhen; Wang, Yuqiang; Zhang, Zaijun; Han, Yifan

Liu, Zheng; Qiu, Xiaoling; Mak, Shinghung; Guo, Baojian; Hu, Shengquan; Wang, Jiajun; Luo, Fangcheng; Xu, Daping; Sun, Yewei; Zhang, Gaoxiao; Cui, Guozhen; Wang, Yuqiang; Zhang, Zaijun; Han, Yifan.

Afiliación

Liu Z; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic Uni
Qiu X; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China.
Mak S; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hung
Guo B; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic Uni
Hu S; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hung
Wang J; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hung
Luo F; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic Uni
Xu D; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hung
Sun Y; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China.
Zhang G; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China.
Cui G; Department of Bioengineering, Zunyi Medical University Zhuhai Campus, Zhuhai, China.
Wang Y; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China.
Zhang Z; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, China. Electronic address: zaijunzhang@163.com.
Han Y; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hung

Chem Biol Interact ; 325: 109020, 2020 Jul 01.

Article en En | MEDLINE | ID: mdl-32092300

Asunto(s)

Calcio/metabolismo; Ácido Glutámico/toxicidad; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Memantina/farmacología; Neuronas/efectos de los fármacos; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Animales; Apoptosis/efectos de los fármacos; Transporte Biológico/efectos de los fármacos; Recuento de Células; Cerebelo/citología; Hipocampo/citología; Memantina/metabolismo; Simulación del Acoplamiento Molecular; Neuronas/citología; Neuronas/metabolismo; Fármacos Neuroprotectores/metabolismo; Fármacos Neuroprotectores/farmacología; Conformación Proteica; Ratas; Ratas Sprague-Dawley; Receptores de N-Metil-D-Aspartato/química; Receptores de N-Metil-D-Aspartato/metabolismo; Transducción de Señal/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Memantina / Calcio / Ácido Glutámico / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Glucógeno Sintasa Quinasa 3 beta / Neuronas Límite: Animals Idioma: En Revista: Chem Biol Interact Año: 2020 Tipo del documento: Article

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