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Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility.
Vega Alanis, Blanca Angelica; Iorio, Maria Teresa; Silva, Luca L; Bampali, Konstantina; Ernst, Margot; Schnürch, Michael; Mihovilovic, Marko D.
Afiliación
  • Vega Alanis BA; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria.
  • Iorio MT; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria.
  • Silva LL; Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany.
  • Bampali K; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.
  • Ernst M; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.
  • Schnürch M; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria.
  • Mihovilovic MD; Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria.
Molecules ; 25(4)2020 Feb 24.
Article en En | MEDLINE | ID: mdl-32102309
ABSTRACT
GABAA receptor modulators are structurally almost as diverse as their target protein. A plethora of heterocyclic scaffolds has been described as modulating this extremely important receptor family. Some made it into clinical trials and, even on the market, some were dismissed. This review focuses on the synthetic accessibility and potential for library synthesis of GABAA receptor modulators containing at least one heterocyclic scaffold, which were disclosed within the last 10 years.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de GABA-A / Bibliotecas de Moléculas Pequeñas / Agonistas de Receptores de GABA-A / Antagonistas de Receptores de GABA-A / Compuestos Heterocíclicos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de GABA-A / Bibliotecas de Moléculas Pequeñas / Agonistas de Receptores de GABA-A / Antagonistas de Receptores de GABA-A / Compuestos Heterocíclicos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Austria