Immunogenicity of rat-neu<sup>+</sup> mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment.

Sow, Heng Sheng; Benonisson, Hreinn; Brouwers, Conny; Linssen, Margot M; Camps, Marcel; Breukel, Cor; Claassens, Jill; van Hall, Thorbald; Ossendorp, Ferry; Fransen, Marieke F; Verbeek, J Sjef

Immunogenicity of rat-neu⁺ mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment.

Sow, Heng Sheng; Benonisson, Hreinn; Brouwers, Conny; Linssen, Margot M; Camps, Marcel; Breukel, Cor; Claassens, Jill; van Hall, Thorbald; Ossendorp, Ferry; Fransen, Marieke F; Verbeek, J Sjef.

Afiliación

Sow HS; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Benonisson H; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Brouwers C; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Linssen MM; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Camps M; Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.
Breukel C; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Claassens J; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
van Hall T; Department of Medical Oncology, Leiden University Medical Centre, Leiden, The Netherlands.
Ossendorp F; Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.
Fransen MF; Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.
Verbeek JS; Department of Pulmonary Diseases, Amsterdam University Medical Centre, Amsterdam, The Netherlands.

Sci Rep ; 10(1): 3933, 2020 03 03.

Article en En | MEDLINE | ID: mdl-32127568

Asunto(s)

Anticuerpos Monoclonales/uso terapéutico; Neoplasias Mamarias Animales/tratamiento farmacológico; Neoplasias Mamarias Animales/inmunología; Neoplasias Mamarias Experimentales/tratamiento farmacológico; Neoplasias Mamarias Experimentales/inmunología; Receptor ErbB-2/antagonistas & inhibidores; Receptor ErbB-2/metabolismo; Linfocitos T/metabolismo; Animales; Anticuerpos Monoclonales Humanizados/uso terapéutico; Linfocitos T CD4-Positivos/efectos de los fármacos; Linfocitos T CD4-Positivos/metabolismo; Linfocitos T CD8-positivos/efectos de los fármacos; Linfocitos T CD8-positivos/metabolismo; Línea Celular Tumoral; Femenino; Citometría de Flujo; Lapatinib/uso terapéutico; Antígenos Comunes de Leucocito/metabolismo; Masculino; Ratones; Ratones Endogámicos BALB C; Quinolinas/uso terapéutico; Ratas; Receptor ErbB-2/genética; Transducción de Señal; Linfocitos T/efectos de los fármacos; Linfocitos T/inmunología; Trastuzumab/uso terapéutico

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T / Neoplasias Mamarias Animales / Receptor ErbB-2 / Neoplasias Mamarias Experimentales / Anticuerpos Monoclonales Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos

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