Formation, interpretation, and regulation of the Drosophila Dorsal/NF-κB gradient.
Curr Top Dev Biol
; 137: 143-191, 2020.
Article
en En
| MEDLINE
| ID: mdl-32143742
ABSTRACT
The morphogen gradient of the transcription factor Dorsal in the early Drosophila embryo has become one of the most widely studied tissue patterning systems. Dorsal is a Drosophila homolog of mammalian NF-κB and patterns the dorsal-ventral axis of the blastoderm embryo into several tissue types by spatially regulating upwards of 100 zygotic genes. Recent studies using fluorescence microscopy and live imaging have quantified the Dorsal gradient and its target genes, which has paved the way for mechanistic modeling of the gradient. In this review, we describe the mechanisms behind the initiation of the Dorsal gradient and its regulation of target genes. The main focus of the review is a discussion of quantitative and computational studies of the Dl gradient system, including regulation of the Dl gradient. We conclude with a discussion of potential future directions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfoproteínas
/
Factores de Transcripción
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Proteínas Nucleares
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FN-kappa B
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Regulación del Desarrollo de la Expresión Génica
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Biología Computacional
/
Tipificación del Cuerpo
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Proteínas de Drosophila
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Drosophila melanogaster
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Embrión no Mamífero
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Curr Top Dev Biol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos