Purine and pyrimidine transporters of pathogenic protozoa - conduits for therapeutic agents.
Med Res Rev
; 40(5): 1679-1714, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32144812
ABSTRACT
Purines and pyrimidines are essential nutrients for any cell. Most organisms are able to synthesize their own purines and pyrimidines, but this ability was lost in protozoans that adapted to parasitism, leading to a great diversification in transporter activities in these organisms, especially for the acquisition of amino acids and nucleosides from their hosts throughout their life cycles. Many of these transporters have been shown to have sufficiently different substrate affinities from mammalian transporters, making them good carriers for therapeutic agents. In this review, we summarize the knowledge obtained on purine and pyrimidine activities identified in protozoan parasites to date and discuss their importance for the survival of these parasites and as drug carriers, as well as the perspectives of developments in the field.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Purinas
/
Proteínas Protozoarias
Límite:
Animals
Idioma:
En
Revista:
Med Res Rev
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido