Pro-opiomelanocortin Neurons and the Transcriptional Regulation of Motivated Exercise.

Good, Deborah J; Zhang, Haiyan; Grange, Robert W; Braun, Thomas

Good, Deborah J; Zhang, Haiyan; Grange, Robert W; Braun, Thomas.

Afiliación

Good DJ; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA.
Zhang H; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA.
Grange RW; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA.
Braun T; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

Exerc Sport Sci Rev ; 48(2): 74-82, 2020 04.

Article en En | MEDLINE | ID: mdl-32168170

RESUMEN

Hypothalamic pro-opiomelanocortin (POMC) neurons are key sensory neurons for energy balance. The basic helix-loop-helix transcription factor NHLH2 is expressed in POMC neurons, and Nhlh2 knockout mice show adult-onset obesity with low exercise behavior. Evidence is presented to explore the hypothesis that NHLH2 transcriptional activity within POMC neurons is crucial for maintaining motivated spontaneous activity and enforced exercise.

Asunto(s)

Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética; Ejercicio Físico/fisiología; Hipotálamo/metabolismo; Motivación/fisiología; Neuronas/metabolismo; Proopiomelanocortina/metabolismo; Transcripción Genética; Animales; Ejercicio Físico/psicología; Humanos; Modelos Animales

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Proopiomelanocortina / Ejercicio Físico / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Hipotálamo / Motivación / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Exerc Sport Sci Rev Año: 2020 Tipo del documento: Article

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