Checkpoint Responses to DNA Double-Strand Breaks.
Annu Rev Biochem
; 89: 103-133, 2020 06 20.
Article
en En
| MEDLINE
| ID: mdl-32176524
ABSTRACT
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
ADN
/
Proteínas de Saccharomyces cerevisiae
/
Reparación del ADN por Unión de Extremidades
/
Reparación del ADN por Recombinación
/
Puntos de Control del Ciclo Celular
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2020
Tipo del documento:
Article