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Epigenetic metabolites license stem cell states.
Somasundaram, Logeshwaran; Levy, Shiri; Hussein, Abdiasis M; Ehnes, Devon D; Mathieu, Julie; Ruohola-Baker, Hannele.
Afiliación
  • Somasundaram L; Department of Biochemistry, University of Washington, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United States.
  • Levy S; Department of Biochemistry, University of Washington, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United States.
  • Hussein AM; Department of Biochemistry, University of Washington, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United States.
  • Ehnes DD; Department of Biochemistry, University of Washington, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United States.
  • Mathieu J; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United States; Department of Comparative Medicine, University of Washington, Seattle, WA, United States.
  • Ruohola-Baker H; Department of Biochemistry, University of Washington, Seattle, WA, United States; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United States. Electronic address: hannele@uw.edu.
Curr Top Dev Biol ; 138: 209-240, 2020.
Article en En | MEDLINE | ID: mdl-32220298
ABSTRACT
It has become clear during recent years that stem cells undergo metabolic remodeling during their activation process. While these metabolic switches take place in pluripotency as well as adult stem cell populations, the rules that govern the switch are not clear. In this review, we summarize some of the transitions in adult and pluripotent cell types and will propose that the key function in this process is the generation of epigenetic metabolites that govern critical epigenetic modifications, and therefore stem cell states.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación del Desarrollo de la Expresión Génica / Células Madre Pluripotentes / Epigénesis Genética / Células Madre Embrionarias / Reprogramación Celular / Metaboloma Límite: Animals / Humans Idioma: En Revista: Curr Top Dev Biol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación del Desarrollo de la Expresión Génica / Células Madre Pluripotentes / Epigénesis Genética / Células Madre Embrionarias / Reprogramación Celular / Metaboloma Límite: Animals / Humans Idioma: En Revista: Curr Top Dev Biol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos