Sutton Naevi as Melanoma Simulators: Can Confocal Microscopy Help in the Diagnosis?
Acta Derm Venereol
; 100(10): adv00134, 2020 May 11.
Article
en En
| MEDLINE
| ID: mdl-32318743
ABSTRACT
Sutton naevi can sometimes present a challenging appearance with atypical presentation, also by dermoscopy. Reï¬ectance confocal microscopy could help in making a diagnosis. This study prospectively collected two groups of Sutton nevi the first one was composed by typical white halo naevi monitored for one year (13, 23%) and the second one was made up of atypical lesions excised in order to rule out melanoma, which were histologically diagnosed as Sutton naevi (21, 37%). These two groups of Sutton naevi were compared to a retrospectively collected cohort of thin melanomas with histologic regression features (23, 40%). On dermoscopy, atypical Sutton naevi and melanomas were indistinguishable. Reï¬ectance confocal microscopy demonstrated significant differences at the dermo-epidermal junction marked dermo-epidermal junction thickening and non-edged papilla were associated with melanoma, while the presence of nests was associated with Sutton naevi. However, reï¬ectance confocal microscopy also detected marked intraepidermal pagetoid cells in Sutton naevi that were a combination of MelanA+ and CD1a+ cells. Sutton naevi can simulate melanoma, under both dermoscopy and reï¬ectance confocal microscopy. Nevertheless, relevant confocal dermo-epidermal junction features and the clinical scenario can be helpful to make a final diagnosis, especially in those situations where melanoma must be ruled out.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
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Microscopía Confocal
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Melanoma
/
Nevo
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Acta Derm Venereol
Año:
2020
Tipo del documento:
Article
País de afiliación:
España