Suppression of Musashi­2 by the small compound largazole exerts inhibitory effects on malignant cells.

Wang, Min; Sun, Xiao-Yan; Zhou, Yong-Chun; Zhang, Kuo-Jun; Lu, Yong-Zhi; Liu, Jinsong; Huang, Yun-Chao; Wang, Gui-Zhen; Jiang, Sheng; Zhou, Guang-Biao

Suppression of Musashi2 by the small compound largazole exerts inhibitory effects on malignant cells.

Wang, Min; Sun, Xiao-Yan; Zhou, Yong-Chun; Zhang, Kuo-Jun; Lu, Yong-Zhi; Liu, Jinsong; Huang, Yun-Chao; Wang, Gui-Zhen; Jiang, Sheng; Zhou, Guang-Biao.

Afiliación

Wang M; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
Sun XY; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
Zhou YC; Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650106, P.R. China.
Zhang KJ; State Key Laboratory of Natural Medicines, and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China.
Lu YZ; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, P.R. China.
Liu J; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, P.R. China.
Huang YC; Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650106, P.R. China.
Wang GZ; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
Jiang S; State Key Laboratory of Natural Medicines, and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China.
Zhou GB; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.

Int J Oncol ; 56(5): 1274-1283, 2020 05.

Article en En | MEDLINE | ID: mdl-32319553

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/genética; Depsipéptidos/farmacología; Leucemia Mielógena Crónica BCR-ABL Positiva/genética; Neoplasias Pulmonares/genética; Proteínas de Unión al ARN/genética; Tiazoles/farmacología; Adulto; Anciano; Animales; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Depsipéptidos/química; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Leucemia Mielógena Crónica BCR-ABL Positiva/tratamiento farmacológico; Neoplasias Pulmonares/tratamiento farmacológico; Masculino; Ratones; Persona de Mediana Edad; Modelos Moleculares; Simulación del Acoplamiento Molecular; Conformación Proteica; Proteínas de Unión al ARN/antagonistas & inhibidores; Proteínas de Unión al ARN/química; Tiazoles/química; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

Musashi-2; inhibitor; non-small cell lung cancer; chronic myeloid leukemia; largazole

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tiazoles / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Unión al ARN / Carcinoma de Pulmón de Células no Pequeñas / Depsipéptidos / Neoplasias Pulmonares Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Oncol Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article

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