Impact of type and severity of postoperative complications on long-term outcomes after colorectal liver metastases resection.
J Surg Oncol
; 122(2): 212-225, 2020 Aug.
Article
en En
| MEDLINE
| ID: mdl-32335938
ABSTRACT
BACKGROUND AND OBJECTIVES:
Postoperative complications (POCs) after hepatic resection for colorectal liver metastases (CRLM) adversely affect long-term survival. The aim of this study was to analyze the effect of POC etiology and severity on overall survival (OS) and disease-free survival (DFS).METHODS:
A retrospective study of 254 consecutive hepatectomies for CRLM was performed. Univariate and multivariate analyses were performed to determine the effects of demographic, tumor-related and perioperative variables on OS and DFS. A 11 propensity score matching (PSM) was then used to compare patients with different POC etiology infective (Inf-POC), noninfective (Non-inf POC), and no-complications (No-POC).RESULTS:
Inf-POC, Non-inf POC, and No-POC patients represented 18.8%, 19.2%, and 62% of the sample, respectively. In univariate and multivariate analyses infectious POC were independent risk factors for decreased OS and DFS. After PSM, Inf-POC group presented decreased OS and DFS when compared with Non-inf POC (5-year OS 31.8% vs 51.6%; P = .05 and 5-year DFS 13.6% vs 31.9%; P = .04) and with No-POC (5-year OS 29.4% vs 58.7%; P = .03 and 5-year DFS 11.8% vs 39.7%; P = .03). There were no differences between Non-inf POC and No-POC patients. POC severity calculated using the Comprehensive Complications Index did not influence OS and DFS before and after PSM.CONCLUSION:
The negative oncological impact of POCs after CRLM resection is determined by infective etiology not by severity.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Hepatectomía
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Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Surg Oncol
Año:
2020
Tipo del documento:
Article
País de afiliación:
España