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MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial.
Sarker, Debashis; Plummer, Ruth; Meyer, Tim; Sodergren, Mikael H; Basu, Bristi; Chee, Cheng Ean; Huang, Kai-Wen; Palmer, Daniel H; Ma, Yuk Ting; Evans, T R Jeff; Spalding, Duncan R C; Pai, Madhava; Sharma, Rohini; Pinato, David J; Spicer, James; Hunter, Sarah; Kwatra, Vineet; Nicholls, Joanna P; Collin, David; Nutbrown, Robert; Glenny, Helen; Fairbairn, Sonia; Reebye, Vikash; Voutila, Jon; Dorman, Stephanie; Andrikakou, Pinelopi; Lloyd, Peter; Felstead, Steve; Vasara, Jenni; Habib, Robert; Wood, Chris; Saetrom, Pal; Huber, Hans E; Blakey, David C; Rossi, John J; Habib, Nagy.
Afiliación
  • Sarker D; King's College London, London, United Kingdom.
  • Plummer R; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Meyer T; University College London Cancer Institute, London, United Kingdom.
  • Sodergren MH; Department of Surgery and Cancer, Imperial College London, London, United Kingdom. mikael.sodergren@imperial.ac.uk nagy.habib@imperial.ac.uk nagy@minatx.com.
  • Basu B; Addenbrooke's Hospital, Cambridge, United Kingdom.
  • Chee CE; National University Cancer Institute Singapore, Singapore.
  • Huang KW; National Taiwan University Hospital, Taipei, Taiwan.
  • Palmer DH; Department of Molecular and Clinical Cancer Medicine, University of Liverpool and Clatterbridge Cancer Centre, Liverpool, United Kingdom.
  • Ma YT; University of Birmingham, Birmingham, United Kingdom.
  • Evans TRJ; University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
  • Spalding DRC; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  • Pai M; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  • Sharma R; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  • Pinato DJ; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  • Spicer J; King's College London, London, United Kingdom.
  • Hunter S; King's College London, London, United Kingdom.
  • Kwatra V; King's College London, London, United Kingdom.
  • Nicholls JP; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  • Collin D; MiNA Therapeutics Ltd., London, United Kingdom.
  • Nutbrown R; MiNA Therapeutics Ltd., London, United Kingdom.
  • Glenny H; MiNA Therapeutics Ltd., London, United Kingdom.
  • Fairbairn S; MiNA Therapeutics Ltd., London, United Kingdom.
  • Reebye V; MiNA Therapeutics Ltd., London, United Kingdom.
  • Voutila J; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  • Dorman S; MiNA Therapeutics Ltd., London, United Kingdom.
  • Andrikakou P; MiNA Therapeutics Ltd., London, United Kingdom.
  • Lloyd P; MiNA Therapeutics Ltd., London, United Kingdom.
  • Felstead S; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  • Vasara J; King's College London, London, United Kingdom.
  • Habib R; MiNA Therapeutics Ltd., London, United Kingdom.
  • Wood C; MiNA Therapeutics Ltd., London, United Kingdom.
  • Saetrom P; MiNA Therapeutics Ltd., London, United Kingdom.
  • Huber HE; MiNA Therapeutics Ltd., London, United Kingdom.
  • Blakey DC; Department of Clinical and Molecular Medicine, Department of Computer and Information Science, Bioinformatics Core Facility-BioCore, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
  • Rossi JJ; BioTD Strategies LLC, Lansdale, Pennsylvania.
  • Habib N; MiNA Therapeutics Ltd., London, United Kingdom.
Clin Cancer Res ; 26(15): 3936-3946, 2020 08 01.
Article en En | MEDLINE | ID: mdl-32357963
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligorribonucleótidos / Carcinoma Hepatocelular / Proteínas Potenciadoras de Unión a CCAAT / Neoplasias Hepáticas / Antineoplásicos Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligorribonucleótidos / Carcinoma Hepatocelular / Proteínas Potenciadoras de Unión a CCAAT / Neoplasias Hepáticas / Antineoplásicos Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido