Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cells.

Cai, Aimin; Zheng, Hailun; Chen, Zhiwei; Lin, Xinlu; Li, Chen; Yao, Qing; Bhutia, Yangzom D; Ganapathy, Vadivel; Chen, Ruijie; Kou, Longfa

Cai, Aimin; Zheng, Hailun; Chen, Zhiwei; Lin, Xinlu; Li, Chen; Yao, Qing; Bhutia, Yangzom D; Ganapathy, Vadivel; Chen, Ruijie; Kou, Longfa.

Afiliación

Cai A; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Zheng H; Wenzhou Municipal Key Laboratory of Paediatric Pharmacy, Wenzhou 325027, China.
Chen Z; Institute of Metabonomics and Medical NMR, Wenzhou Medical University, Wenzhou 325035, China.
Lin X; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Li C; Wenzhou Municipal Key Laboratory of Paediatric Pharmacy, Wenzhou 325027, China.
Yao Q; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Bhutia YD; Wenzhou Municipal Key Laboratory of Paediatric Pharmacy, Wenzhou 325027, China.
Ganapathy V; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Chen R; Wenzhou Municipal Key Laboratory of Paediatric Pharmacy, Wenzhou 325027, China.
Kou L; Institute of Metabonomics and Medical NMR, Wenzhou Medical University, Wenzhou 325035, China.

Biochem J ; 477(10): 1923-1937, 2020 05 29.

Article en En | MEDLINE | ID: mdl-32379301

Asunto(s)

Desoxicitidina/análogos & derivados; Sinergismo Farmacológico; Neoplasias Pancreáticas/tratamiento farmacológico; Triptófano/análogos & derivados; Sistemas de Transporte de Aminoácidos/antagonistas & inhibidores; Sistemas de Transporte de Aminoácidos/metabolismo; Aminoácidos/efectos de los fármacos; Aminoácidos/metabolismo; Antineoplásicos; Protocolos de Quimioterapia Combinada Antineoplásica; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Desoxicitidina/uso terapéutico; Humanos; Metabolómica; Neoplasias Pancreáticas/patología; Triptófano/metabolismo; Triptófano/uso terapéutico; Gemcitabina

Palabras clave

1H-NMR-based metabolomics; SLC6A14; combination therapy; gemcitabine; pancreatic cancer; α-methyltryptophan

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Triptófano / Desoxicitidina / Sinergismo Farmacológico Límite: Humans Idioma: En Revista: Biochem J Año: 2020 Tipo del documento: Article País de afiliación: China

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