Sequential Visible-Light and <i>N</i>-Heterocyclic Carbene Catalysis: Stereoselective Synthesis of Tetrahydropyrano[2,3-<i>b</i>]indoles.

Wang, Chengyuan; Wang, Zheyuan; Yang, Jin; Shi, Shi-Hui; Hui, Xin-Ping

Sequential Visible-Light and N-Heterocyclic Carbene Catalysis: Stereoselective Synthesis of Tetrahydropyrano[2,3-b]indoles.

Wang, Chengyuan; Wang, Zheyuan; Yang, Jin; Shi, Shi-Hui; Hui, Xin-Ping.

Afiliación

Wang C; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Wang Z; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Yang J; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Shi SH; Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, Yan'an University, Yan'an 716000, Shaanxi, P. R. China.
Hui XP; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.

Org Lett ; 22(11): 4440-4443, 2020 Jun 05.

Article en En | MEDLINE | ID: mdl-32380832

RESUMEN

An efficiently stereoselective [4 + 2] cycloaddition of 3-alkylenyloxindoles and α-diazoketones through sequential visible-light photoactivation and N-heterocyclic carbene catalysis was achieved. A series of tetrahydropyrano[2,3-b]indoles with an all-carbon quaternary stereocenter were obtained in good yields with excellent diastereo- and enantioselectivities.

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article

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