Association of CYP19A1 gene variations with adjuvant letrozole-induced adverse events in South Indian postmenopausal breast cancer cohort expressing hormone-receptor positivity.

Umamaheswaran, Gurusamy; Kadambari, Dharanipragada; Muthuvel, Suresh Kumar; Kalaivani, Sekar; Devi, Jaganathan; Damodaran, Solai Elango; Pradhan, Suresh Chandra; Dubashi, Biswajit; Dkhar, Steven Aibor; Adithan, Chandrasekaran

Umamaheswaran, Gurusamy; Kadambari, Dharanipragada; Muthuvel, Suresh Kumar; Kalaivani, Sekar; Devi, Jaganathan; Damodaran, Solai Elango; Pradhan, Suresh Chandra; Dubashi, Biswajit; Dkhar, Steven Aibor; Adithan, Chandrasekaran.

Afiliación

Umamaheswaran G; Department of Pharmacology, Centre for Advanced Research in Pharmacogenomics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India. umagenes@gmail.com.
Kadambari D; Department of Oncology, Institute of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden. umagenes@gmail.com.
Muthuvel SK; Departments of Surgery and Medical Education, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Kalaivani S; School of Life Sciences, Centre for Bioinformatics, Pondicherry University, Puducherry, India.
Devi J; Department of Pharmacology, Centre for Advanced Research in Pharmacogenomics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Damodaran SE; Department of Animal Sciences, University of Connecticut, Storrs, USA.
Pradhan SC; Department of Pharmacology, Centre for Advanced Research in Pharmacogenomics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Dubashi B; Department of Pharmacology, Centre for Advanced Research in Pharmacogenomics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Dkhar SA; Department of Medical Oncology, Regional Cancer Center, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Adithan C; Department of Pharmacology, Centre for Advanced Research in Pharmacogenomics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Breast Cancer Res Treat ; 182(1): 147-158, 2020 Jul.

Article en En | MEDLINE | ID: mdl-32385792

Asunto(s)

Aromatasa/genética; Neoplasias de la Mama/tratamiento farmacológico; Letrozol/efectos adversos; Adulto; Anciano; Anciano de 80 o más Años; Antineoplásicos/efectos adversos; Antineoplásicos/uso terapéutico; Aromatasa/metabolismo; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Quimioterapia Adyuvante; Estudios de Cohortes; Femenino; Estudios de Seguimiento; Humanos; Incidencia; India; Letrozol/uso terapéutico; Persona de Mediana Edad; Polimorfismo de Nucleótido Simple; Posmenopausia; Pronóstico; Receptor ErbB-2/metabolismo; Receptores de Estrógenos/metabolismo; Receptores de Progesterona/metabolismo

Palabras clave

Aromatase; Breast cancer; Estrogen; Letrozole; Musculoskeletal toxicity; SNP; South Indian; Vasomotor symptoms

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Aromatasa / Letrozol Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Breast Cancer Res Treat Año: 2020 Tipo del documento: Article País de afiliación: India

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