Pd(II)-Catalyzed Direct Î³-C(sp3)-H Arylation between Free ß2-Amino Esters and ß3-Amino Esters and Aryl Iodides Using a Catalytic Transient Directing Group.

Wang, Zhaohui; Fu, Yangjie; Zhang, Qiyu; Liu, Hong; Wang, Jiang

Pd(II)-Catalyzed Direct Î³-C(sp³)-H Arylation between Free ß²-Amino Esters and ß³-Amino Esters and Aryl Iodides Using a Catalytic Transient Directing Group.

Wang, Zhaohui; Fu, Yangjie; Zhang, Qiyu; Liu, Hong; Wang, Jiang.

Afiliación

Wang Z; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Fu Y; State Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Zhang Q; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Liu H; State Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Wang J; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.

J Org Chem ; 85(12): 7683-7693, 2020 06 19.

Article en En | MEDLINE | ID: mdl-32423204

RESUMEN

Pd(II)-catalyzed direct Î³-C(sp3)-H arylation coupling with free ß2-amino esters and ß3-amino esters using a commercially available catalytic transient directing group has been developed. This approach features high efficiency, broad substrate tolerance, easily accessible starting materials, and mild reaction conditions.

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2020 Tipo del documento: Article País de afiliación: China

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