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Self-Assembly of Mitochondria-Targeted Photosensitizer to Increase Photostability and Photodynamic Therapeutic Efficacy in Hypoxia.
Jana, Batakrishna; Thomas, Ajesh P; Kim, Sangpil; Lee, In Seong; Choi, Huyeon; Jin, Seongeon; Park, Soo Ah; Min, Seung Kyu; Kim, Chaekyu; Ryu, Ja-Hyoung.
Afiliación
  • Jana B; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Thomas AP; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Kim S; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Lee IS; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Choi H; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Jin S; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Park SA; In Vivo Research Center, UNIST, Central Research Facilities, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
  • Min SK; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Kim C; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
  • Ryu JH; Department of chemistry, Ulsan National Institute of, Science and Technology (UNIST), Ulsan, 44919, South Korea.
Chemistry ; 26(47): 10695-10701, 2020 Aug 21.
Article en En | MEDLINE | ID: mdl-32428292
ABSTRACT
The development of photosensitizers for cancer photodynamic therapy has been challenging due to their low photostability and therapeutic inefficacy in hypoxic tumor microenvironments. To overcome these issues, we have developed a mitochondria-targeted photosensitizer consisting of an indocyanine moiety with triphenylphosphonium arms, which can self-assemble into spherical micelles directed to mitochondria. Self-assembly of the photosensitizer resulted in a higher photostability by preventing free rotation of the indoline ring of the indocyanine moiety. The mitochondria targeting capability of the photosensitizer allowed it to utilize intramitochondrial oxygen. We found that the mitochondria-targeted photosensitizer localized to mitochondria and induced apoptosis of cancer cells both normoxic and hypoxic conditions through generation of ROS. The micellar self-assemblies of the photosensitizer were further confirmed to selectively localize to tumor tissues in a xenograft tumor mouse model through passive targeting and showed efficient tumor growth inhibition.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Hipoxia de la Célula / Fármacos Fotosensibilizantes / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Corea del Sur

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Hipoxia de la Célula / Fármacos Fotosensibilizantes / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Corea del Sur