The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes.

James, Nicole E; Emerson, Jenna B; Borgstadt, Ashley D; Beffa, Lindsey; Oliver, Matthew T; Hovanesian, Virginia; Urh, Anze; Singh, Rakesh K; Rowswell-Turner, Rachael; DiSilvestro, Paul A; Ou, Joyce; Moore, Richard G; Ribeiro, Jennifer R

James, Nicole E; Emerson, Jenna B; Borgstadt, Ashley D; Beffa, Lindsey; Oliver, Matthew T; Hovanesian, Virginia; Urh, Anze; Singh, Rakesh K; Rowswell-Turner, Rachael; DiSilvestro, Paul A; Ou, Joyce; Moore, Richard G; Ribeiro, Jennifer R.

Afiliación

James NE; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.
Emerson JB; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.
Borgstadt AD; Warren-Alpert Medical School of Brown University, Providence, RI, USA.
Beffa L; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.
Oliver MT; Warren-Alpert Medical School of Brown University, Providence, RI, USA.
Hovanesian V; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.
Urh A; Warren-Alpert Medical School of Brown University, Providence, RI, USA.
Singh RK; Women and Infants Hospital, Department of Obstetrics and Gynecology, Program in Women's Oncology, Providence, RI, USA.
Rowswell-Turner R; Warren-Alpert Medical School of Brown University, Providence, RI, USA.
DiSilvestro PA; Rhode Island Hospital, Digital Imaging and Analysis Core Facility, Providence, RI, USA.
Ou J; Northwell Health Physician Partners Gynecologic Oncology, Brightwaters, NY, USA.
Moore RG; University of Rochester Medical Center, Rochester, NY, USA.
Ribeiro JR; University of Rochester Medical Center, Rochester, NY, USA.

Sci Rep ; 10(1): 8558, 2020 05 22.

Article en En | MEDLINE | ID: mdl-32444701

Asunto(s)

Biomarcadores de Tumor/metabolismo; Regulación Neoplásica de la Expresión Génica; Neovascularización Patológica/patología; Neoplasias Ováricas/patología; Factor de Transcripción STAT3/metabolismo; Microambiente Tumoral/inmunología; Proteína 2 de Dominio del Núcleo de Cuatro Disulfuros WAP/metabolismo; Adulto; Biomarcadores de Tumor/genética; Estudios de Casos y Controles; Movimiento Celular; Proliferación Celular; Femenino; Estudios de Seguimiento; Humanos; Persona de Mediana Edad; Neovascularización Patológica/genética; Neovascularización Patológica/metabolismo; Neoplasias Ováricas/irrigación sanguínea; Neoplasias Ováricas/inmunología; Neoplasias Ováricas/metabolismo; Pronóstico; Factor de Transcripción STAT3/genética; Células Tumorales Cultivadas; Proteína 2 de Dominio del Núcleo de Cuatro Disulfuros WAP/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Factor de Transcripción STAT3 / Microambiente Tumoral / Proteína 2 de Dominio del Núcleo de Cuatro Disulfuros WAP / Neovascularización Patológica Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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