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Haematopoietic stem cell self-renewal in vivo and ex vivo.
Wilkinson, Adam C; Igarashi, Kyomi J; Nakauchi, Hiromitsu.
Afiliación
  • Wilkinson AC; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Igarashi KJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • Nakauchi H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Nat Rev Genet ; 21(9): 541-554, 2020 09.
Article en En | MEDLINE | ID: mdl-32467607
ABSTRACT
The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system homeostasis throughout life and underlies the curative capacity of clinical HSC transplantation therapies. However, despite extensive characterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive. This Review presents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas Límite: Animals / Humans Idioma: En Revista: Nat Rev Genet Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas Límite: Animals / Humans Idioma: En Revista: Nat Rev Genet Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos