Your browser doesn't support javascript.
loading
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability.
McDermott, Jason E; Arshad, Osama A; Petyuk, Vladislav A; Fu, Yi; Gritsenko, Marina A; Clauss, Therese R; Moore, Ronald J; Schepmoes, Athena A; Zhao, Rui; Monroe, Matthew E; Schnaubelt, Michael; Tsai, Chia-Feng; Payne, Samuel H; Huang, Chen; Wang, Liang-Bo; Foltz, Steven; Wyczalkowski, Matthew; Wu, Yige; Song, Ehwang; Brewer, Molly A; Thiagarajan, Mathangi; Kinsinger, Christopher R; Robles, Ana I; Boja, Emily S; Rodriguez, Henry; Chan, Daniel W; Zhang, Bing; Zhang, Zhen; Ding, Li; Smith, Richard D; Liu, Tao; Rodland, Karin D.
Afiliación
  • McDermott JE; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Arshad OA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97201, USA.
  • Petyuk VA; These authors contributed equally.
  • Fu Y; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Gritsenko MA; These authors contributed equally.
  • Clauss TR; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Moore RJ; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
  • Schepmoes AA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Zhao R; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Monroe ME; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Schnaubelt M; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Tsai CF; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Payne SH; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Huang C; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
  • Wang LB; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Foltz S; Department of Biology, Brigham Young University, Provo, UT 84602, USA.
  • Wyczalkowski M; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Wu Y; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Song E; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA.
  • Brewer MA; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA.
  • Thiagarajan M; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA.
  • Kinsinger CR; The McDonnell Genome Institute, Washington University in St. Louis, St Louis, MO 63108, USA.
  • Robles AI; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Boja ES; Department of Obstetrics and Gynecology, University of Connecticut, Farmington, CT 06030, USA.
  • Rodriguez H; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  • Chan DW; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Zhang B; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Zhang Z; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Ding L; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Smith RD; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
  • Liu T; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Rodland KD; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Cell Rep Med ; 1(1)2020 04 21.
Article en En | MEDLINE | ID: mdl-32529193
ABSTRACT
In the absence of a dominant driving mutation other than uniformly present TP53 mutations, deeper understanding of the biology driving ovarian high-grade serous cancer (HGSC) requires analysis at a functional level, including post-translational modifications. Comprehensive proteogenomic and phosphoproteomic characterization of 83 prospectively collected ovarian HGSC and appropriate normal precursor tissue samples (fallopian tube) under strict control of ischemia time reveals pathways that significantly differentiate between HGSC and relevant normal tissues in the context of homologous repair deficiency (HRD) status. In addition to confirming key features of HGSC from previous studies, including a potential survival-associated signature and histone acetylation as a marker of HRD, deep phosphoproteomics provides insights regarding the potential role of proliferation-induced replication stress in promoting the characteristic chromosomal instability of HGSC and suggests potential therapeutic targets for use in precision medicine trials.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Fosfotransferasas / Cistadenocarcinoma Seroso / Inestabilidad Cromosómica / Replicación del ADN Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Cell Rep Med Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Fosfotransferasas / Cistadenocarcinoma Seroso / Inestabilidad Cromosómica / Replicación del ADN Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Cell Rep Med Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos