Neutrophil: lymphocyte ratio is positively associated with subclinical diabetic cardiomyopathy.
BMC Endocr Disord
; 20(1): 99, 2020 Jun 30.
Article
en En
| MEDLINE
| ID: mdl-32605653
ABSTRACT
BACKGROUND:
Subclinical diabetic cardiomyopathy (DCM) occurs frequently in asymptomatic subjects with Type 2 diabetes mellitus (T2DM). The direct association between the immune system and DCM with effective biomarkers has been demonstrated in previous studies.METHODS:
Five hundred seven subjects with T2DM were recruited from April 2018 to October 2019 and divided into T2DM with cardiac dysfunction (DCM) group and T2DM without cardiac dysfunction (non-DCM) group. The relationship between the quartiles of Neutrophil lymphocyte ratio (NLR) and subclinical DCM was evaluated by using adjusted logistic regression models.(covariates age, sex, BMI, duration of diabetes, and hyperlipidemia).RESULTS:
Blood NLR was significantly upregulated in DCM group compared to non-DCM group (P = 0.05). Then the adjusted odds ratio (95% CI) of the highest NLR quartile was 14.32 (2.92-70.31) compared with the lowest quartile of NLR after multiple adjusted (P < 0.001). However, there was no significant relation between neutrophil and lymphocyte counts and the occurrence of DCM in T2DM patients.CONCLUSIONS:
This study demonstrated that NLR was associated with the occurrence of subclinical DCM, suggesting that NLR may be a biomarker for predicting DCM with effectiveness and accuracy. TRIAL REGISTRATION Chinese Clinical Trial Registry (ChiCTR1900027080) . Registered 30 October 2019. Retrospectively registered www.medresman.org.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Biomarcadores
/
Diabetes Mellitus Tipo 2
/
Cardiomiopatías Diabéticas
/
Neutrófilos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
BMC Endocr Disord
Año:
2020
Tipo del documento:
Article
País de afiliación:
China