Role of myeloid cells in the regulation of group 2 innate lymphoid cell-mediated allergic inflammation.
Immunology
; 161(1): 18-24, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32609880
ABSTRACT
Group 2 innate lymphoid cells (ILC2s) are an important component of the innate immune system that execute important effector functions at barrier surfaces, such as lung and skin. Like T helper type 2 cells, ILC2s are able to release high amounts of type 2 cytokines that are essential in inducing allergic inflammation and eliminating helminth infections. The past few years have contributed to our better understanding of the interactions between ILC2s and other cells of the immune system via soluble factors or in a cell-cell contact manner. Myeloid cells, including mononuclear leukocytes and polymorphonuclear leukocytes, are excellent sensors of tissue damage and infection and can influence ILC2 responses in the process of allergic inflammation. In this review, we summarize recent insights on how myeloid cell subsets regulate ILC2 activation with focus on soluble factors in the context of allergic inflammation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Células Mieloides
/
Dermatitis Atópica
/
Inmunidad Innata
Límite:
Humans
Idioma:
En
Revista:
Immunology
Año:
2020
Tipo del documento:
Article
País de afiliación:
China