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Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4ß-triazolopodophyllotoxin conjugates.
Zi, Cheng-Ting; Yang, Liu; Hu, Yue; Zhang, Pan; Tang, Han; Zhang, Bang-Lei; Shen, Xiao-Jing; Kong, Qing-Hua; Wang, Ya; Wang, Xuan-Jun; Sheng, Jun.
Afiliación
  • Zi CT; Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
  • Yang L; College of Science, Yunnan Agricultural University, Kunming 650201, China.
  • Hu Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • Zhang P; Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
  • Tang H; Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
  • Zhang BL; Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
  • Shen XJ; Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
  • Kong QH; College of Science, Yunnan Agricultural University, Kunming 650201, China.
  • Wang Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • Wang XJ; Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
  • Sheng J; College of Science, Yunnan Agricultural University, Kunming 650201, China.
J Asian Nat Prod Res ; 23(8): 772-780, 2021 Aug.
Article en En | MEDLINE | ID: mdl-32619100
ABSTRACT
Two new (-)-epigallocatechin-3-gallate-4ß-triazolopodophyllotoxin conjugates (7 and 8) were synthesized and evaluated for biological activity. Compound 8 showed highly potent anticancer activity against A-549 cell line with IC50 of 2.16 ± 1.02 µM, which displayed the highest selectivity index value (SI = 14.5) in A-549 cells. Molecular docking indicated that compound 8 could bind with the active site of Top-II. Therefore, compound 8 might be a promising candidate for further development.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Catequina / Antineoplásicos Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Catequina / Antineoplásicos Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China