Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model.

Borahay, Mostafa A; Vincent, Kathleen L; Motamedi, Massoud; Tekedereli, Ibrahim; Salama, Salama A; Ozpolat, Bulent; Kilic, Gokhan S

Borahay, Mostafa A; Vincent, Kathleen L; Motamedi, Massoud; Tekedereli, Ibrahim; Salama, Salama A; Ozpolat, Bulent; Kilic, Gokhan S.

Afiliación

Borahay MA; Department of Gynecology & Obstetrics, Johns Hopkins University, 4940 Eastern Ave, Baltimore, MD, 21224-2780, USA. mboraha1@jhmi.edu.
Vincent KL; Department of Obstetrics and Gynecology, and Biomedical Engineering Center, University of Texas Medical Branch, Galveston, TX, USA.
Motamedi M; Biomedical Engineering Center, University of Texas Medical Branch, Galveston, TX, USA.
Tekedereli I; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Salama SA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Ozpolat B; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. bozpolat@mdanderson.org.
Kilic GS; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.

Reprod Sci ; 28(1): 271-277, 2021 01.

Article en En | MEDLINE | ID: mdl-32632769

Asunto(s)

2-Metoxiestradiol/farmacología; Antineoplásicos/farmacología; Leiomioma/tratamiento farmacológico; Neoplasias Uterinas/tratamiento farmacológico; 2-Metoxiestradiol/química; Animales; Antineoplásicos/química; Apoptosis/efectos de los fármacos; Caspasa 3/metabolismo; Proliferación Celular/efectos de los fármacos; Composición de Medicamentos; Femenino; Humanos; Antígeno Ki-67/metabolismo; Leiomioma/metabolismo; Leiomioma/patología; Liposomas; Ratones Endogámicos NOD; Ratones SCID; Nanopartículas; Carga Tumoral/efectos de los fármacos; Neoplasias Uterinas/metabolismo; Neoplasias Uterinas/patología; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

2-ME; 2-methoxyestradiol; 2ME; Fibroid; Leiomyoma; Liposomes; Nanoparticles; Treatment

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Uterinas / 2-Metoxiestradiol / Leiomioma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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